Forever Young Microbe Discovered That is Immune to Ageing
While ageing remains an inevitable fact of life, Max Planck researchers have discovered a microbe that stays forever young by rejuvenating every time it reproduces. The findings provide fundamental insights into the mechanisms of ageing.
In general, even symmetrically dividing microbes do not split into two exactly identical halves. Detailed investigations revealed that there are mechanisms in place that ensure that one half receives older, often defective, cell material, whereas the other half is equipped with new fully-functional material. So microbes produce offspring that is younger than the parent – like is the case with humans.
The research team showed that, unlike other species, the yeast Schizosaccheromyces pombe is immune to ageing when reproducing under favourable growth conditions. When the yeast is treated well, it reproduces by splitting into two halves that both inherit their fair share of old cell material. As both cells get only half of the damaged material, they are both younger than before. “The yeast is rejuvenated a bit every time it reproduces,” explains Iva Tolic-Norrelykke, research group leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden and lead investigator on the project.