Theoretical Possibility of Giant Hollow Magnetic Cage Molecules Discovered

Physicists discovered the possibility of creating large, hollow magnetic cage molecules that could one day be used in medicine as a drug delivery system to non-invasively treat tumors, and in other emerging technologies.

Approximately 25 years ago, scientists first made the discovery of the football-shaped C₆₀ fullerene – also known as the Buckminster Fullerene – a molecule composed of 60 carbon atoms that formed a hollow cage. Due to its unique hollow cage structure the molecule offers serious technological potential because it could hold other atoms or small molecules inside, and therefore, be used in applications such as drug delivery.

That potential has since spurred worldwide interest among scientists who have been searching for similar molecules. Although some hollow cage structures have been found, none of them is magnetic. Magnetic properties of the structure are of particular interest because a hollow magnetic structure carrying an embedded atom or molecule can be guided by an external magnetic field and may serve as an effective vehicle for targeted drug delivery.

In a new study, published online on July 22 in The Journal of Chemical Physics, two VCU scientists employing state-of-the-art theoretical methods show that magnetic hollow cages larger than the original C₆₀ fullerene that carry giant magnetic moments are possible.

“The potential benefit of this finding is that it provides a route to the synthesis of molecular magnets with colossal magnetic moments,” said co-lead investigator Puru Jena, Ph.D., distinguished professor of physics in the VCU College of Humanities and Sciences. Jena collaborated with Menghao Wu, Ph.D., co-author of the paper and a postdoctoral scholar in the VCU Department of Physics.

“These molecules can be used for targeted non-invasive drug delivery. When assembled, the molecules can also form new high strength magnets for device application,” Jena said.

According to Jena, the pair of VCU researchers demonstrated the magnetic moment of the molecule by focusing on hetero-atomic clusters consisting of transition metal atoms such as cobalt (Co) and manganese (Mn) and carbon (C) atoms.

According to Jena, the team is still early in its discovery process. “Ways must be found to synthesize large quantities of these molecules and study their magnetic properties once they are assembled. Finally, these molecules need to be functionalized by embedding desired atoms/molecules for practical applications.” -- Virginia Commonwealth University

Reference:

Menghao Wu and Puru Jena, Magnetic hollow cages with colossal moments, Journal of Chemical Physics, 2013, DOI: 10.1063/1.4813022