Gluten Allergy in Children with Autism May Cause Problems with Gastrointestinal Health

A recent study reveals that some children with autism show elevated levels of immune system antibodies to gluten proteins.

Research from the study suggests that these findings could help address the cause and treatment of gastrointestinal disorders that may accompany autism spectrum disorders. Diets excluding gluten have become popular in the autism community. However, the effectiveness of these dietary lifestyles has not yet been confirmed.

Lead researcher Armin Alaedini, an assistant professor of medical sciences at Columbia University Medical Center in New York City, believes that "there appears to be an increased immune reactivity to gluten in children with autism, which is associated with gastrointestinal symptoms," she said, via the study.

The findings did not link autism with Celiac disease.

For those with Celiac disease, an inherited autoimmune disorder where gluten must be avoided, they'll have the chance to enjoy pastries from a popular chain without having to replicate a similar recipe, minus gluten, of course, at home.

As gluten is a kind of protein typically found in foods such as bread, crackers and pasta, those with Celiac disease cannot handle the compound as it harms their immune system and small intestines, preventing the absorption of nutrients.

Statistics show that the disease affects as many as 1 in 133 in the United States alone, and without treatment, can lead to iron deficiency, osteoporosis, an increased risk of Lymphoma, and slowed growth and weakened bones in children.

The study notes that Alaedini's team reviewed the medical records and blood samples of 140 children, 37 of whom had autism. Researchers tested the blood samples for antibodies to a marker of Celiac disease and antibodies to gliadin, a marker of gluten. Patients participating in the study were also tested for genes associated with the disorder.

Researchers believe that higher levels of antibodies to gluten could point to immune and/or intestinal abnormalities in the affected children.

While more research needs to be conducted with further studies, the authors believe that these findings do not suggest that putting a child with autism on a gluten-free diet has any added benefit. 

The findings regarding the study can be found in the June issue of PLuS One.